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DNA/RNA Synthesizer Manufacturer for Automated Oligonucleotide Synthesis

Specializing in high-throughput synthesizers, multi-functional dispensing workstations, deprotection modules, and full-spectrum synthesis consumables for global biopharma laboratories.

Empowering Global Life Sciences with End-to-End Oligo Solutions

Hunan Honya Biotech Co., Ltd. specializes in DNA/RNA synthesis equipment, oligonucleotide synthesis reagents, and consumables. We provide automated synthesis solutions designed to support molecular biology research, oligonucleotide production, and laboratory applications.

Honya Biotech focuses on DNA/RNA Synthesizers, Dispensing Reaction Integration Workstations, Pipetting and Elution Workstations, Deprotection Equipment, Amidite Dissolved Equipment, Purification Workstations, Synthesis Columns, Phosphoramidites, Modification Amidites, Synthesis Reagents, and various consumables to provide you with the fastest and most efficient DNA/RNA synthesis products and services in the world.

We are constantly improving the performance of our products, perfecting our production process, and getting the details right. We not only provide you with high-quality products but also deliver complete technical training and service. Our professional management staff, technical engineers, and maintenance personnel ensure seamless after-sales support worldwide.

10+ Years
DNA/RNA Synthesis Expertise
>90%
Independent Intellectual Property
100%
Customization Available
Global
Support & Installation Network
Honya Biotech Modern Facility
Hunan Honya Biotech Co., Ltd. - Marketing Center
Overseas Marketing Center
Overseas Marketing & Technical Division
Qingdao Laboratory Modified Amidite R&D
Qingdao Laboratory - Modified Amidite R&D Center
Beijing Factory Equipment R&D
Beijing Factory - Equipment R&D & Production

Explore Our DNA/RNA Synthesizer & Modular Equipment

Our DNA/RNA synthesizer portfolio includes different equipment configurations to support various oligonucleotide synthesis requirements. Whether establishing a new synthesis workflow or scaling up industrial production, our team configures the ideal solution.

Full Automatic Pipetting Workstation with liquid transfer

Full Automatic Pipetting Workstation with Liquid Transfer

High-precision microplate liquid transfer system designed for high-throughput oligonucleotide handling, sample dilution, and enzymatic preparation.

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HY-15 DNA/RNA Oligo Synthesizer

HY-15 DNA/RNA Oligo Synthesizer

Precision multi-column synthesizer engineered for flexible research scale, specialized fluorescent probes, modified RNA, and custom phosphoramidite chemistry.

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HY 12 DNA RNA Oligo Synthesizer for Medium synthesis

HY 12 DNA RNA Oligo Synthesizer (Medium Synthesis)

Medium-throughput column platform tailored for clinical oligo pilot development, antisense oligonucleotides (ASO), and diagnostic primer lots.

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HY 12 DNA RNA Oligo Synthesizer for Medium synthesis

HY 12 Advanced Oligo Synthesizer Platform

Fully automated pneumatic delivery system providing superior coupling efficiency and reduced reagent consumption for 12 parallel synthesis lines.

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Deprotection equipment for Cutting DNA sequence

Deprotection Equipment for Cleavage & Deprotection

Automated thermal gas and liquid phase deprotection bath optimized for fast cleavage of synthesized DNA/RNA chains from solid CPG supports.

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Elution Equipment use for wash nucleic acid

Elution Equipment for Washing Nucleic Acids

Automated pressure-controlled wash system engineered for high-recovery purification preparation, desalting columns, and solid-phase extraction.

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Purification Equipment for Oligo purification

Purification Equipment for Oligo Purification

Integrated cartridge and reverse-phase extraction station ensuring high purity rates for gene synthesis, PCR diagnostics, and therapeutic targets.

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Phosphoramidite Dissolving Equipment

Phosphoramidite Dissolving Equipment

Automated anhydrous dissolution chamber preventing reagent oxidation, eliminating moisture interference, and ensuring stoichiometric amidite activation.

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Multi function Workstation Customizable

Multi-Function Customizable Workstation

Modular robotic handling platform integrating pipetting, dispensing, reagent addition, and temperature control into one unified automated enclosure.

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Modified Amidite CPG for Oligo synthesis

Modified Amidite & CPG for Oligo Synthesis

High-purity chemical phosphoramidite reagents including Cy3/Cy5 fluorophores, biotin tags, amine linkers, inverted dT, and thiol modifications.

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Universal CPG for empty synthesis column

Universal CPG Support for Empty Synthesis Columns

Controlled Pore Glass (500Å/1000Å) and high-load supports engineered for superior initial yield across universal synthesis column designs.

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Phosphoramidite for DNA RNA Synthesis

Standard & Specialized Phosphoramidites

Ultra-pure dA, dC, dG, and dT phosphoramidite reagents, activator solutions, oxidation reagents, capping agents, and deblocking solutions.

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Integrated Oligonucleotide Synthesis Products

Beyond synthesizers, Honya Biotech offers complementary equipment, reagents, and consumables for different stages of oligonucleotide synthesis. This product portfolio allows customers to source multiple components of their synthesis workflow from one supplier.

1. Reagent Prep & Dissolution

Ensuring pristine dry conditions using Amidite Dissolving Equipment and high-grade phosphoramidites before starting the chain elongation cycle.

2. Automated Synthesis

HY-12 and HY-192 Synthesizers execute iterative deblocking, coupling, capping, and oxidation cycles with ultra-low dead volume.

3. Cleavage & Deprotection

Specialized Deprotection Units quickly release oligo fragments from solid supports while eliminating protecting groups without degradation.

4. Elution & Purification

Complete purification workstations, elution equipment, desalting columns, and high-recovery plates for downstream qPCR and NGS.


Applications of DNA/RNA Synthesis Equipment

Automated DNA/RNA synthesis equipment is used in various molecular biology applications, including PCR primer preparation, DNA sequencing research, hybridization probes, and other oligonucleotide-based laboratory workflows. The appropriate synthesizer configuration depends on synthesis scale, throughput requirements, oligonucleotide chemistry, and laboratory workflow.

PCR & qPCR Primers

Rapid synthesis of standard and modified DNA oligonucleotides designed for high-sensitivity diagnostic assays, point-of-care kits, and disease surveillance.

NGS Target Enrichment

Production of high-fidelity probe panels and barcoded adaptors vital for targeted deep sequencing, exome sequencing, and library preparation workflows.

RNA Therapeutics & ASO

Dedicated RNA synthesis setups supporting phosphorothioate backbones, 2'-OMe, 2'-MOE, and GalNAc conjugates for antisense and siRNA research.

Gene Synthesis & Assembly

High-efficiency generation of long oligomers used to construct synthetic genes, enzymatic pathways, expression cassettes, and metabolic engineering constructs.

CRISPR sgRNA Guides

Ultra-pure single guide RNA synthesis enabling precision gene knockout, CRISPR-Cas editing studies, and cell therapy pipeline development.

Fluorescent Probes & Aptamers

Automated integration of quenchers, dyes, and custom modified amidites for real-time cellular imaging, in situ hybridization, and biosensing.


Why Choose Honya Biotech?

Combining advanced mechanical engineering with specialized synthetic chemistry to provide dependable automation systems for commercial and scientific leaders.

10+ Years of Field Experience

More than 10 years of proven innovation in DNA/RNA synthesis engineering, supporting scientific facilities, diagnostic developers, and universities worldwide.

Integrated Ecosystem Sourcing

One-stop provider covering high-precision synthesizers, liquid handlers, deprotection chambers, amidite reagents, solid supports, and consumables.

>90% Proprietary IP

Over 90% of our products are independently researched, designed, and manufactured with intellectual property rights, guaranteeing cost-efficiency and reliable parts supply.

Full Equipment Customization

We tailor fluidic channels, valve configurations, reaction plate geometries, and software protocols to align with your laboratory synthesis scale.

Expert Technical Training

We provide operational commissioning, staff training courses, maintenance walkthroughs, and chemistry optimization to ensure rapid productivity.

Direct Manufacturer Support

Rapid response times, direct factory engineer access, guaranteed spare parts inventory, and preventative service agreements protect your lab uptime.


Frequently Asked Questions

Clear answers regarding automated synthesizer mechanisms, chemistry compatibility, setup requirements, and customization.

What is a DNA/RNA synthesizer used for?
A DNA/RNA synthesizer is an automated instrument that chemically builds nucleic acid chains with user-defined base sequences using the phosphoramidite method. It delivers reagents to solid support columns in automated cyclic steps (deblocking, activation & coupling, capping, oxidation) to manufacture primers, fluorescent probes, antisense oligos, and synthetic genes.
What is the difference between DNA and RNA synthesis equipment?
While both operate on solid-phase phosphoramidite chemistry, RNA synthesis requires extra protection on the 2'-hydroxyl group (such as 2'-TBDMS or 2'-TOM). Consequently, RNA coupling steps require longer reaction times, sensitive inert gas seals against ambient moisture, and unique deprotection steps. Honya synthesizers feature gas control and customizable software timers to run both DNA and RNA synthesis effortlessly.
Can DNA/RNA synthesizers support different synthesis requirements?
Yes. Our systems are engineered to handle various scales—from nanomolar volumes for routine diagnostic PCR primers to micromolar/millimolar scales for therapeutic discovery. The fluidic valves can be mapped for custom phosphorothioate backbones, peptide nucleic acids, and multiple dye-labeled amidites.
Can Honya Biotech customize synthesis equipment?
Yes. With in-house mechanical, fluidic, and software engineering teams, Honya Biotech provides full OEM/ODM customizations. We modify channel capacities (e.g., HY-12 to HY-192), integrate automated pipetting arms, adjust bottle cap manifolds, and implement client-tailored automation software interfaces.
What supporting reagents and consumables are available?
Honya Biotech delivers a complete chemical supply chain: standard & modified phosphoramidites (dA, dC, dG, dT, 2'-OMe, Cy3, Cy5, Biotin, etc.), universal and base-loaded CPG solid supports, synthesis columns, specialty bottle closures, activator solutions, oxidation reagents, and deblocking solutions.

Request a DNA/RNA Synthesizer Quotation

Looking for an automated DNA/RNA synthesizer for your laboratory or production workflow? Contact Honya Biotech to discuss your application, equipment configuration, and customization requirements.

Direct Phone Support
+86 18973156202
Official Sales Email
sale@honyabio.cn
WhatsApp / Mobile Inquiry
+86 18973156202